Our Science
Unlocking the Power of Collagen Peptides through Decades of Research & DevelopmentAward-Winning Collagen Ingredients
As part of the Wellnex global brand, Nitta Gelatin introduced Replenwell™ as its premier line of performance optimized, clinically proven, collagen peptide ingredients in 2020. Within its first year on the market, Replenwell™ was honored as NutraIngredients-USA’s 2021 Ingredient of the Year, and NutraIngredients-ASIA’s 2021 finalist for Ingredient of the Year.
Leaders in the Discovery of Bioactive Dipeptides “PO” and “OG”
Over a decade ago, Wellnex was the first collagen peptide supplier to successfully identify the bioactive dipeptides proline-hydroxyproline “PO,” and hydroxyproline-glycine “OG,” from within the collagen peptide molecule.
Bioavailability trials revealed PO and OG in high concentrations within the human bloodstream following oral consumption of Wellnex collagen peptides. Additional studies confirmed accumulation of these bioactive compounds in specific tissues, including the skin and cartilage, via radio labeling. Detection of PO in human urine following consumption also indicate that these dipeptides are uniquely resistant to peptidases (enzymes that break down peptides into single amino acids) within the human body.
Building on this body of scientific knowledge, multiple human clinical trials have confirmed that collagen peptides with higher levels of PO-OG elicit greater physiological benefits, when compared to standard collagen peptide ingredients, over the same dosage and duration.
Only Wellnex Replenwell™ offers unique collagen products with up to 30 times the PO-OG content of standard collagen peptides. Ultra high levels of bioactive dipeptides lead to smaller effective serving sizes, better cost-in-use, and greater versatility in product applications.
Global Recognition
As Japan’s “Food with Function Claim” (FFC) category draws global attention, Wellnex collagen peptides were honored to be the first and only collagen ingredient in Japan to be awarded dual claims for the improvement of skin moisture AND skin elasticity. In order to be approved under the FFC system, food companies are required to submit stringent scientific evidence, including human clinical trials, to Japan’s Consumer Affairs Agency (CAA), in support of their claims. Since becoming the first collagen ingredient to enter into the CAA’s FCC review process, Nitta’s Wellnex collagen peptides have been incorporated into many best-selling “beauty-from-within” products within the Asian marketplace.
Advancing Knowledge through Scientific Discovery
Leading in innovation, Wellnex collagen peptides are supported by over 25 patents for cutting-edge processes, research theories, and proprietary applications. Our patents include:
PATENTS IN JAPAN
JPB 4523339 – Collagen Peptides, Agent for Supporting Healthy Bone Density
JPB 4490498 – Collagen Peptides, Agent for Supporting Healthy Bone Density
JPB 5361155 – Decomposition Gelatin Powder and Production Method
JPB 4490498 – Collagen Peptides, Di-Peptide and Agent for Health Support (Bone, Joint, Wound Healing)
JPB 4547015 – Effervescent Beverage and Beverage Foaming Agent
JPB 4904021 – Collagen Peptide- Containing Cosmetic Composition and Manufacturing Method Thereof
JPB 5361155 – Method for Producing Hydrolyzed Gelatin (Collagen Peptides)
JPB 4377522 – Production Method for Stable Acidic Milk Beverages with Collagen Peptides
JPB 4709730 – Collagen Peptides in Chewable Tablet
JPB 5612131 – Agent for Blood Sugar Support
JPB 5778692 – Agent for Blood Sugar Support
JPB 6100364 – Specific Collagen derived Peptides, Agent to Support more even Skin Tone
JPB 3881453 – Collagen Peptides for Calcium Absorption Enhancement
JPB 6240447 – Elastin Production Promoter
JPB 6407029 – Peptide Mixture to Promote Myoblast Differentiation
PATENTS IN THE UNITED STATES
US 8227424 B2 – Collagen Peptides, Di-Peptide to Support Healthy Bone Density
US 9061003 B2 – Agent for Blood Sugar Support
US 8410062 B2 – Collagen Peptide, Dipeptide, and Malady inhibitor
US 2014024596 A1 – Collagen Peptides, Di – and Tri-Peptide, Agent to Support Healthy Blood Sugar
US 2016082087 A1 – Specific Collagen derived Peptides, Agent to Support more even Skin Tone
US 10632177 B2 – Peptide Mixture to Promote Myoblast Differentiation
INTERNATIONAL PATENTS
WO/2010/038323A1 – Collagen Peptides, Di-Peptide and Agent to Support Healthy Bone Density
WO/2012/102308 – Collagen Peptides as a Therapeutic Agent for Diabetes
WO/2019/235292A1 – Polypeptide with Specific Di-Peptide Sequence, Agent to Support Scar Suppression
WO/2014/092150A1 – Polypeptide with Specific Di-Peptide Sequence, Agent to Promote Myoblast Differentiation
WO/2014/175001A1 – Specific Collagen derived Peptides, Agent to Support more even Skin Tone
WO/2012/081531A1 – Agent for Blood Sugar Support