Wellnex Clinical Study Supports Joint Comfort and Reduction of Inflammatory Markers in Athletes

by | Feb 22, 2022

Our latest sports and active nutrition innovations are highlight in this month’s issue of Prepared Foods Magazine.

Wellnex Replenwell’s sports nutrition product is Collapep JB. The “JB” alludes to joint and bone health, and the product has been clinically tested to support joint comfort and suppress 3-methylhistidine (biomarker for skeletal muscle protein breakdown) and interleukin-6 (inflammatory cytokine associated with joint discomfort) in young, healthy long-distance runners.

Compared to other collagen peptides, what distinguishes Collapep JB is its proprietary, concentrated ratio of functional di-peptides proline-hydroxyproline, “PO,” and hydroxyproline-glycine, “OG.” Collapep JB is confirmed to suppress the activity of alkaline phosphatase (ALP), which promotes calcification of joints. Meanwhile, Collapep JB significantly increases production of aggrecan, a lubricant for cartilage, in chondrogenic ATDC5 cells.

The functional dipeptide PO within Collapep JB is absorbed to the bloodstream following ingestion, and it enhances the expression of the gene called Runx2, which promotes calcification and is involved in promoting osteoblast differentiation. Osteoblasts are specialized cells which help make new bones. For bone support, PO activates the enzyme ERK in osteoblasts, and is also considered to have effects on the transcription factor Foxg1.

Be sure to read the full article to learn how to incorporate collagen ingredients proven to support athletic performance into your brand’s bars, beverages, gummies, and more.