New Human Clinical Trial Supports Collagen Peptide Supplementation for a More Even Skin Tone

by | Oct 21, 2022

Beauty is more than skin deep, and Wellnex Replenwell collagen peptide ingredients are here to prove just that! In our 6th published, peer reviewed human clinical trial for skin support, it was determined that 5g daily supplementation over just one month resulted in a significant reduction in facial skin pigmented patches and redness.

Our Wellnex team began partnering with top researchers in Japan over a decade ago, with the goals of identifying and characterizing the bioactive components within the collagen molecule. These collaborations allowed us to really “look under the hood,” and understand the specific mechanisms of action affecting health and beauty. Following human absorption studies, two dipeptides stood out for their ability to remain intact throughout the digestion process, effectively allowing them to accumulate within the bloodstream and migrate to specific tissues including skin and cartilage. These unique dipeptides were identified as proline-hydroxyproline, or “PO,” and hydroxyproline-glycine, “OG.” In vitro and in vivo studies confirmed the physiological functionality of these collagen-derived dipeptides as related to differentiation, proliferation, and migration of skin cells.

Building on this “PO-OG theory,” we’re proud to contribute a total of 6 randomized, double-blind, placebo-controlled human clinical trials showing significant improvements in the reduction of the visible signs of skin aging including wrinkles, roughness, dryness, loss of elasticity, and uneven skin tone. While “standard” collagen peptides have been found to deliver skin benefits over placebo, collagen peptides with concentrated levels of PO-OG, such as the ingredient used in this most recent study, produce even greater results when compared to standard collagen peptides. Wellnex Replenwell is currently the only B2B collagen ingredient lineup available with concentrated levels of PO-OG. With previous studies supporting effective dosages as low as 2.5 grams daily over only 4 weeks, we pride ourselves on leading the way in collagen innovation for holistic skin support.