The Science Behind Radiant Skin

Beautiful Skin Basics

Age-associated changes in skin tone and texture are easily recognizable, and include dryness, roughness, hyperpigmentation, and wrinkles.

Skin is comprSoft skin makes me smileised of two layers, known as the epidermis and dermis. The dermis contains proteins such as collagen and elastin, and glycosaminoglycans including hyaluronic acid. Collagen provides integrity and firmness to the skin, and is responsible for its strength and elasticity. The degradation of collagen in the skin leads to the reduced skin firmness, enhanced photo-damage, fine lines, and wrinkles.

As we age, our body’s natural ability to produce collagen decreases. Healthy radiance begins to vanish, and our skin starts to develop ridges, fine lines, uneven tone and age spots, while losing elasticity and moisture.

These signs of aging can be slowed by maintaining collagen and hyaluronic acid levels within the skin. Because glycine, proline, and hydroxyproline are the major amino acid components of collagen, replenishing these amino acids may assist in maintaining collagen levels within the skin. Additionally, high levels of two key bioactive dipeptides in Wellnex Replenwell™, proline-hydroxyproline (PO) and hydroxyproline-glycine (OG), have been shown to enhance fibroblast (skin cell) proliferation, stimulate hyaluronic acid production, and affect gene expression associated with healthy skin and hair cycles, in peer-reviewed scientific studies.

Replenwell™ Collagen Peptides – An Ingredient for Youthful-looking Skin

Natural collagen exists as the triple-helical rigid structure, which is insoluble and not readily absorbed within the human body in its native form. However, Wellnex Replenwell™ collagen peptides are a hydrolyzed, bioavailable form of collagen, providing amino acids and key dipeptides (PO & OG) essential for the maintenance of optimum skin health.

Studies have established Wellnex Replenwell™ collagen peptides as highly digestible, and quickly absorbed into the bloodstream when consumed as part of a finished food or supplement. Pharmacological bioavailability trials revealed that dipeptides PO & OG were available at high concentrations for several hours in the human blood stream after oral administration due to their resistance to biological enzymatic degradation.

Results of an in vitro study using dermal fibroblasts display the ability of dipeptides PO & OG to enhance cellular proliferation and hyaluronic acid synthesis. These findings suggest a correlation between the presence of PO & OG and skin improvements noted in a later study ; including increased skin moisture and elasticity and reduced roughness and UV spots.

Low Daily Dosage with High Clinical Impact

In a recent randomized, double-blind, placebo-controlled (RDBPC) clinical study, 2.5g daily consumption of Wellnex Replenwell™ was associated with a statistically significant increase in skin hydration and elasticity, and a reduction in roughness, in as little as 4 weeks.

The Replenwell™ Difference

Wellnex is currently the only collagen ingredient available with concentrated levels of bioactive dipeptides PO & OG, when compared to standard collagen peptides.

Now with 5 gold-standard RDBPC human clinical trials for beauty, Wellnex Replenwell™ is Nitta Gelatin’s premier line of collagen ingredients. Clinically tested for safety and efficacy, you can be confident that your products will deliver beauty-from-within benefits that stand out from the rest*:

  • Increase in skin moisture
  • Increase in skin elasticity
  • Reduction in UV-induced Spots
  • Improvements in skin texture
  • Reduction in skin roughness



*These statements have not been evaluated by the Food and Drug Administration.  This product is not intended to diagnose, treat, cure or prevent any disease.