Bioavailability

Bioavailability refers to the ability of a substance to be absorbed and utilized within the body. While standard, native collagen may have some effect on health and wellness, the large molecules are not easily absorbed once ingested.  Through our proprietary hydrolysis process, Wellnex collagen peptides are clinically proven to be highly bioavailable.

Bioavailability trials revealed that two types of Wellnex collagen dipeptides, proline-hydroxyproline (Pro-Hyp) and hydroxyproline-glycine (Hyp-Gly), were available at high concentrations in the human blood stream after oral consumption. Hyp-Gly  were found up to 4 hours after ingestion. (Sugihara F, Inoue N, Kuwamori M, Taniguchi M: Quantification of hydroxyprolyl-glycine Hyp-Gly in human blood after ingestion of collagen hydrolysate.J Biosci Bioengi 2012;113:202-203).

Absorption Graph

In another study, researchers determined that one of the key di-peptides, Pro-Hyp, could be found within skin cells and bone tissue after ingestion. As you can see from the images below, C-labelled Pro-Hyp reaches the skin and bone tissues rapidly (indicated by the darker spots in picture).

(Kawaguchi T, Nanbu NP, Kurokawa M: Distribution of prolylhydroxyproline and its metabolites after oral administration in rats.Biol Pharm Bull 2012;35:422-427)

Bioavailability

Moreover, Pro-Hyp was identified in the urine after collagen peptide intake (Meilman EB, Urivetzky MM, Rapoport MC: Urinary hydroxyproline peptides. J Clin Invest 1963;42:40-50). These findings suggest that Pro-Hyp and Hyp-Gly are stable and relatively resistant to peptidases in the blood and demonstrate that collagen peptides are able to reach the skin tissues (Liu C, Sugita K, Nihei K, Yoneyama K, Tanaka H: Absorption of hydroxyproline-containing peptides in vascularly perfused rat small intestine in situ. Biosci Biotechnol Biochem 2009;73:1741-1747).

 

*These statements have not been evaluated by the Food and Drug Administration.  This product is not intended to diagnose, treat, cure or prevent any disease.