Bioavailability

Wellnex Collagen Peptides are highly bioavailable and are proven to be so in a publish clinical study.

Bioavailability trials revealed that two types of Wellnex collagen dipeptides, proline-hydroxyproline (Pro-Hyp) and hydroxyproline-glycine (Hyp-Gly), were available at high concentrations in the human blood stream after oral consumption. Hyp-Gly  were found up to 4 hours after ingestion.1)Sugihara F, Inoue N, Kuwamori M, Taniguchi M: Quantification of hydroxyprolyl-glycine Hyp-Gly in human blood after ingestion of collagen hydrolysate.J Biosci Bioengi 2012;113:202-203.

Absorption Graph

In another study, researchers studies if one of the key di-peptides, Pro-Hyp, could be found in actual cells in skin and bone issue after ingestion. As you can see from the images below, C-labelled Pro-Hyp reaches the skin and bone tissues rapidly, which is indicated by the dark spot in picture. 2)Kawaguchi T, Nanbu NP, Kurokawa M: Distribution of prolylhydroxyproline and its metabolites after oral administration in rats.Biol Pharm Bull 2012;35:422-427

Bioavailability

Moreover, Pro-Hyp was identified in the urine after collagen hydrolysate intake.3)Meilman EB, Urivetzky MM, Rapoport MC: Urinary hydroxyproline peptides. J Clin Invest 1963;42:40-50. These findings suggest that Pro-Hyp and Hyp-Gly are stable and relatively resistant to peptidases in the blood and demonstrate that collagen peptides are able to reach the skin tissues.4)Liu C, Sugita K, Nihei K, Yoneyama K, Tanaka H: Absorption of hydroxyproline-containing peptides in vascularly perfused rat small intestine in situ. Biosci Biotechnol Biochem 2009;73:1741-1747.

 

References   [ + ]

1. Sugihara F, Inoue N, Kuwamori M, Taniguchi M: Quantification of hydroxyprolyl-glycine Hyp-Gly in human blood after ingestion of collagen hydrolysate.J Biosci Bioengi 2012;113:202-203.
2. Kawaguchi T, Nanbu NP, Kurokawa M: Distribution of prolylhydroxyproline and its metabolites after oral administration in rats.Biol Pharm Bull 2012;35:422-427
3. Meilman EB, Urivetzky MM, Rapoport MC: Urinary hydroxyproline peptides. J Clin Invest 1963;42:40-50.
4. Liu C, Sugita K, Nihei K, Yoneyama K, Tanaka H: Absorption of hydroxyproline-containing peptides in vascularly perfused rat small intestine in situ. Biosci Biotechnol Biochem 2009;73:1741-1747.